Author  
Place of duty  
Title   국소 진행성 비소세포폐암에 대한 Cisplatin 과 경구 Etoposide 를 사용한 방사선 화학 동시요법의 치료효과 ( Concurrent Chemoradiation Therapy with Cisplatin and Oral Etoposide for Locally Advanced Non - small Cell Lung Cancer )
Publicationinfo   2000 Jan; 032(04): 682-690.
Key_word   Non - small cell lung cancer, Cisplatin, Oral etoposide, Chemoradiation
Full-Text  
Abstract   Purpose: Prognosis of locally advanced inoperable non-small cell lung cancer (NSCLC) treated with radiation therapy alone has been disappointing. In recent years, concurrent chemoradiation therapy has potential of improving both local and metastatic disease-free survival. This phase II study was undertaken to determine the feasibility, toxicity, response rate, local control rate, and survival duration of locally advanced NSCL patients treated with concurrent chemoradiation using cisplatin and oral etoposide. Material and Methods: Forty-seven patients were enrolled and forty-one patients were evaluable. Chemotheray consisted of cisplatin 50 mg2/m/IV on days 1 and 8 and oral etoposide 100 mg/day on days 1 to 5 and 8 to 12 which was repeated, every 4 weeks for two cycles during radiation therapy, Radiation therapy was administered to a total dose of 6300 cGY. Results: Among 41 evaluable patients, six patients achieved complete response, and twenty had partial response, for an overall response rate of 63.4% (95% confidence interval; 48.4% to 75.4%). Stable disease was reported in 10 patients (24.4%) and another 5 (12.2%) showed disease progression. Overall survival rate was 76% at 1 year, 34% at 2 years. Median survival duration was 17 months (range; 3+ to 41+). Eighty-three percents of patients had radiation pneumonitis but only one patients needed medical treatment. Conclusion: Concurrent chemoradiation therapy with cisplatin and oral etoposide at this level is a well tolerated and feasible.
저 자   백창원(Chang Won Paek),윤소영(So Young Yoon),서재홍(Jae Hong Seo),최철원(Chul Won Choi),김병수(Byung Soo Kim),신상원(Sang Won Shin),김열홍(Yeul Hong Kim),심재정(Jae Jung Shim),강경호(Kyung Ho Kang),김준석(Jun Suk Kim)